Immunobiology & Cancer Research Program
What We Do

The Immunobiology and Cancer Research Program, led by Paul W. Kincade, Ph.D., is principally concerned with understanding the normal development and function of cells in the immune system. We hope this research will, in turn, help shed light on disease, as abnormalities in these processes result in leukemia, lymphomas and immunodeficiency diseases. Although astonishing progress has been made, we have much to learn if we are truly to conquer these conditions.
Work in all six laboratories in this program progressed in important ways during the last year. Xiao-Hong Sun, Ph.D., obtained new insights into how highly controlled, cell-type specific degradation mechanisms can help regulate a family of transcription factors. Work in the laboratory of Carol Webb, Ph.D., revealed important interactions between Bruton’s tyrosine kinase and the activity of the Bright transcription factor.
Using an exciting new strain of knockout mice, Linda Thompson, Ph.D., and colleagues found an important role for the CD73 ectoenzyme in hypoxia. Mark Coggeshall, Ph.D., and his lab found intracellular signaling pathways that keep immune system responses within normal ranges. Jose Alberola-Ila, M.D.Ph.D. recently discovered andimportant requirement for NKT cell development. Lorin Olson, Ph.D., recently joined the program and brings exciting new models of fibrotic conditions. Finally, Kincade and his colleagues identified the earliest lymphocyte progenitors within murine bone marrow and are learning how lymphocyte formation can be affected during infectious disease.
Our Scientists
Our Publications

2013
Iwayama T, Olson LE. Involvement of PDGF in Fibrosis and Scleroderma: Recent Insights from Animal Models and Potential Therapeutic Opportunities. Curr Rheumatol Rep 15:304, 2013. [Abstract]
Shen W, Tremblay MS, Deshmukh VA, Wang W, Filippi CM, Harb G, Zhang YQ, Kamireddy A, Baaten JE, Jin Q, Wu T, Swoboda JG, Cho CY, Li J, Laffitte BA, McNamara P, Glynne R, Wu X, Herman AE, Schultz PG. Small-Molecule Inducer of beta Cell Proliferation Identified by High-Throughput Screening. J Am Chem Soc 135:1669-1672, 2013. [Abstract]
Thompson LF, Tsukamoto H, Chernogorova P, Zeiser R. A delicate balance: CD73-generated adenosine limits the severity of graft vs. host disease but also constrains the allogeneic graft vs. tumor effect. Oncoimmunology 2:e22107, 2013. [Abstract]
Zhang Q, Iida R, Yokota T, Kincade PW. Early events in lymphopoiesis: an update. Curr Opin Hematol 2013. [Abstract] EPub
Zhao Y, Ling F, Wang HC, Sun XH. Chronic TLR Signaling Impairs the Long-Term Repopulating Potential of Hematopoietic Stem Cells of Wild Type but Not Id1 Deficient Mice. PLoS One 8:e55552, 2013. [Abstract]
* Indicates publications by more than one department.
Contact Us

Immunobiology & Cancer Research Program
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 23
Oklahoma City, OK 73104
Phone: (405) 271-7905
Fax: (405) 271-8568
Email: paul-kincade@omrf.org



