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Free Radical Biology & Aging Research Program

       What We Do

Scientists in our program study free radicals, the highly reactive molecules capable of inducing oxidative damage to DNA, protein, and lipids. The intra- and extracellular content of these species increase during a variety of diseases. Free radical damage is therefore believed to contribute to the accompanying degeneration of physiologic function. Paradoxically, free radicals are also generated in response to normal physiologic stimuli and can exert reversible effects on protein function indicative of metabolic regulation.

       Our Publications


Hofmann JW, Zhao X, De Cecco M., Peterson AL, Pagliaroli L, Manivannan J, Hubbard GB, Ikeno Y, Zhang Y, Feng B, Li X, Serre T, Qi W, Van Remmen H, Miller RA, Bath KG, de Cabo R., Xu H, Neretti N, Sedivy JM. Reduced expression of MYC increases longevity and enhances healthspan. Cell 160:477-488,2015. [Abstract]

Kwak HB, Lee Y, Kim JH, Van Remmen H, Richardson AG, Lawler JM. MnSOD overexpression reduces fibrosis and pro-apoptotic signaling in the aging mouse heart. J Gerontol A Biol Sci Med Sci 2015. [Abstract] EPub

Plafker KS, Plafker SM. The ubiquitin conjugating enzyme, UBE2E3 and its import receptor, Importin-11 regulate the localization and activity of the anti-oxidant transcription factor NRF2. Mol Biol Cell  26:327-338, 2015. [Abstract]

Wong KE, Mikus CR, Slentz DH, Seiler SE, Debalsi KL, Ilkayeva OR, Crain KI, Kinter MT, Kien CL, Stevens RD, Muoio DM. Muscle-specific overexpression of PGC-1alpha does not augment metabolic improvements in response to exercise and caloric restriction. Diabetes 2015. [Abstract] EPub

Cai A, Hutchison E, Hudson J, Kawashima Y, Komori N, Singh A, Brush RS, Anderson RE, Sonntag WE, Matsumoto H, Griffin TM. Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice. Osteoarthritis Cartilage 22:1301-1309, 2014. [Abstract]

Debalsi KL, Wong KE, Koves TR, Slentz DH, Seiler SE, Wittmann AH, Ilkayeva OR, Stevens RD, Perry CG, Lark DS, Hui ST, Szweda L, Neufer PD, Muoio DM. Targeted  metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle. J Biol Chem 289:8106-8120,2014. [Abstract]

Ding L, Cheng R, Hu Y, Takahashi Y, Jenkins AJ, Keech AC, Humphries KM, Gu X, Elliott MH, Xia X, Ma JX. Peroxisome proliferator-activated receptor alpha protects capillary pericytes in the retina. Am J Pathol  184:2709-2720,2014. [Abstract]

Hill S, Van Remmen H. Mitochondrial stress signaling in longevity: A new role for mitochondrial function in aging. Redox Biol 2:936-944, 2014. [Abstract]

Kanan Y, Siefert JC, Kinter M, Al-Ubaidi MR. Complement Factor H, vitronectin, and opticin are tyrosine-sulfated proteins of the retinal pigment epithelium. PLoS One 9:e105409, 2014. [Abstract]

* Lim HY, Wang W, Chen J, Ocorr K, Bodmer R. ROS Regulate cardiac function via a distinct paracrine mechanism. Cell Rep 7:35-44, 2014. [Abstract]

Lu J, Li W, Du X, Ewert DL, West MB, Stewart C, Floyd RA, Kopke RD. Antioxidants reduce cellular and functional changes induced by intense noise in the inner ear and cochlear nucleus. J Assoc Res Otolaryngol 15:353-372, 2014. [Abstract]

Nguyen L, Plafker KS, Starnes A, Cook MJ, Klevit RE, Plafker SM. The Ubiquitin conjugating enzyme, UBCM2, is restricted to monoubiquitylation by a two-fold mechanism that involves backside residues of the E2 and LYS-48 of ubiquitin. Biochemistry 53:4004-4014, 2014. [Abstract]

Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell 157:565-579, 2014. [Abstract]

Pulliam DA, Deepa SS, Liu Y, Hill S, Lin AL, Bhattacharya A, Shi Y, Sloane L, Viscomi C, Zeviani M, Van Remmen H. Complex IV deficient Surf1-/- mice initiate mitochondrial stress responses. Biochem J 462:359-371, 2014. [Abstract]

Shi Y, Ivannikov MV, Walsh ME, Liu Y, Zhang Y, Jaramillo CA, Macleod GT, Van Remmen H. The lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength in mice. PLoS One 9:e100834, 2014. [Abstract]

* Tran KM, Li Y, Duan H, Arora D, Lim HY, Wang W. Identification of small molecules that protect pancreatic beta cells against endoplasmic reticulum stress-induced cell death. ACS Chem Biol 9:2796-2806, 2014.[Abstract]

Wanagat J, Ahmadieh N, Bielas JH, Ericson NG, Van Remmen H. Skeletal muscle mitochondrial DNA deletions are not increased in CuZn-superoxide dismutase deficient mice. Exp Gerontol 61C:15-19, 2014. [Abstract]

* Yao L, Heuser-Baker J, Herlea-Pana O, Zhang N, Szweda LI, Griffin TM, Barlic-Dicen J. Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet-induced obesity. FASEB J 28:4534-4550,2014. [Abstract]

* Zhao Y, Ling F, Griffin TM, He T, Towner R, Ruan H, Sun XH. Up-regulation of the Sirtuin 1 ( Sirt1) and peroxisome proliferator-activated receptor gamma coactivator-1alpha genes in white adipose tissue of Id1 deficient mice: implications in the protection against diet and age-induced glucose intolerance. J Biol Chem 289:29112-29122, 2014. [Abstract]

* Indicates publications by more than one department or program.

       Contact Us

Free Radical Biology & Aging Research Program
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 21
Oklahoma City, OK 73104

Phone: (405) 271-7570
Fax: (405) 271-1437