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Free Radical Biology & Aging Research Program

       What We Do

Scientists in our program study free radicals, the highly reactive molecules capable of inducing oxidative damage to DNA, protein, and lipids. The intra- and extracellular content of these species increase during a variety of diseases. Free radical damage is therefore believed to contribute to the accompanying degeneration of physiologic function. Paradoxically, free radicals are also generated in response to normal physiologic stimuli and can exert reversible effects on protein function indicative of metabolic regulation.

       Our Publications


Allen BG, Bhatia SK, Buatti JM, Brandt KE, Lindholm KE, Button AM, Szweda LI, Smith B, Spitz DR, Fath MA. Ketogenic Diets Enhance Oxidative Stress and Radio-Chemo-Therapy Responses in Lung Cancer Xenografts. Clin Cancer Res 19:3905-3913, 2013. [Abstract]

Bhatnagar A, Unal H, Jagannathan R, Kaveti S, Duan ZH, Yong S, Vasanji A, Kinter M, Desnoyer R, Karnik SS. Interaction of G-Protein betagamma Complex with Chromatin Modulates GPCR-Dependent Gene Regulation. PLoS One 8:e52689, 2013. [Abstract]

Crewe C, Kinter M, Szweda LI. Rapid Inhibition of Pyruvate Dehydrogenase: An Initiating Event in High Dietary Fat-Induced Loss of Metabolic Flexibility in the Heart. PLoS One 8:e77280, 2013. [Abstract]

* Garteiser P, Doblas S, Towner RA, Griffin TM. Calibration of a semi-automated segmenting method for quantification of adipose tissue compartments from magnetic resonance images of mice. Metabolism  62:1686-1695, 2013. [Abstract]

Ghosh S, Willard B, Comhair S, Dibello P, Xu W, Shiva S, Aulak KS, Kinter M, Erzurum SC. Disulfide bond as a switch for copper-zinc superoxide dismutase activity in asthma. Antioxid Redox Signal  18:412-423, 2013. [Abstract]

Hallgren KW, Zhang D, Kinter M, Willard B, Berkner KL. Methylation of gamma-carboxylated Glu (Gla) allows detection by liquid chromatography-mass spectrometry and the identification of Gla residues in the gamma-glutamyl carboxylase. J Proteome Res 12:2365-2374, 2013. [Abstract]

Hardas SS, Sultana R, Clark AM, Beckett TL, Szweda LI, Murphy MP, Butterfield DA. Oxidative modification of lipoic acid by HNE in Alzheimer disease brain. Redox Biol 1:80-85, 2013. [Abstract]

Macdonald MJ, Langberg EC, Tibell A, Sabat G, Kendrick MA, Szweda LI, Ostenson CG. Identification of ATP Synthase As a Lipid Peroxide Protein Adduct in Pancreatic Islets From Humans With and Without Type 2 Diabetes Mellitus. J Clin Endocrinol Metab 98:E727-E731, 2013. [Abstract]

McLain AL, Cormier PJ, Kinter M, Szweda LI. Glutathionylation of alpha-Ketoglutarate Dehydrogenase: The Chemical Nature and Relative Susceptibility of the Cofactor Lipoic Acid to Modification. Free Radic Biol Med 61C:161-169, 2013. [Abstract]

O'Conor CJ, Griffin TM, Liedtke W, Guilak F. Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet. Ann Rheum Dis 72:300-304,  2013. [Abstract]

Perry EA, Castellani RJ, Moreira PI, Nunomura AA, Liu Q, Harris PL, Sayre LM, Szweda PA, Szweda LI, Zhu X, Smith MA, Perry G. Neurofilaments are the Major Neuronal Target of Hydroxynonenal Mediated Protein Crosslinks. Free Radic Res  47:507-510, 2013. [Abstract]

Rindler PM, Crewe CL, Fernandes J, Kinter M, Szweda LI. Redox Regulation of Insulin Sensitivity due to Enhanced Fatty Acid Utilization in the Mitochondria. Am J Physiol Heart Circ Physiol 305:H634-H643, 2013. [Abstract]

Rindler PM, Plafker SM, Szweda LI, Kinter M. High dietary fat selectively increases catalase expression within cardiac mitochondria. J Biol Chem 288:1979-1990,2013. [Abstract]

Thiagarajan PS, Akbasli AC, Kinter MT, Willard B, Cathcart MK. Vimentin is a target of PKCbeta phosphorylation in MCP-1-activated primary human monocytes. Inflamm Res 62:991-1001, 2013. [Abstract]

* Towner RA, Smith N, Saunders D, Lupu F, Silasi-Mansat R, West M, Ramirez DC, Gomez-Mejiba SE, Bonini MG, Mason RP, Ehrenshaft M, Hensley K. In Vivo Detection of Free Radicals using Molecular MRI and Immuno-Spin-Trapping in a Mouse Models for Amyotrophic Lateral Sclerosis (ALS). Free Radic Biol Med 65C:828-837, 2013. [Abstract]

Vadvalkar SS, Baily CN, Matsuzaki S, West M, Tesiram YA, Humphries KM. Metabolic inflexibility and protein lysine acetylation in heart mitochondria of a chronic model of Type 1 diabetes. Biochem J 449:253-261, 2013. [Abstract]

* Wang S, Wen F, Wiley GB, Kinter MT, Gaffney PM. An Enhancer Element Harboring Variants Associated with Systemic Lupus Erythematosus Engages the TNFAIP3 Promoter to Influence A20 Expression. PLoS Genet 9:e1003750, 2013. [Abstract]


Debalsi KL, Wong KE, Koves TR, Slentz DH, Seiler SE, Wittmann AH, Ilkayeva OR, Stevens RD, Perry CG, Lark DS, Hui ST, Szweda L, Neufer PD, Muoio DM. Targeted Metabolomics Connects Thioredoxin-Interacting Protein ( TXNIP) to Mitochondrial Fuel Selection and Regulation of Specific Oxidoreductase Enzymes in Skeletal Muscle. J Biol Chem 289:8106-8120, 2014. [Abstract]

* Lim HY, Wang W, Chen J, Ocorr K, Bodmer R. ROS Regulate Cardiac Function via a Distinct Paracrine Mechanism. Cell Rep 2014. [Abstract] EPub

* Indicates publications by more than one department or program.

       Contact Us

Free Radical Biology & Aging Research Program
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 21
Oklahoma City, OK 73104

Phone: (405) 271-7570
Fax: (405) 271-1437