What We Do
Scientists in our program study free radicals, the highly reactive molecules capable of inducing oxidative damage to DNA, protein, and lipids. The intra- and extracellular content of these species increase during a variety of diseases. Free radical damage is therefore believed to contribute to the accompanying degeneration of physiologic function. Paradoxically, free radicals are also generated in response to normal physiologic stimuli and can exert reversible effects on protein function indicative of metabolic regulation.
Debalsi KL, Wong KE, Koves TR, Slentz DH, Seiler SE, Wittmann AH, Ilkayeva OR, Stevens RD, Perry CG, Lark DS, Hui ST, Szweda L, Neufer PD, Muoio DM. Targeted Metabolomics Connects Thioredoxin-Interacting Protein (TXNIP) to Mitochondrial Fuel Selection and Regulation of Specific Oxidoreductase Enzymes in Skeletal Muscle. J Biol Chem 289:8106-8120,2014. [Abstract]
* Lim HY, Wang W, Chen J, Ocorr K, Bodmer R. ROS Regulate Cardiac Function via a Distinct Paracrine Mechanism. Cell Rep 7:35-44, 2014. [Abstract]
Nguyen L, Plafker KS, Starnes A, Cook MJ, Klevit RE, Plafker SM. The Ubiquitin conjugating enzyme, UBCM2, is restricted to monoubiquitylation by a two-fold mechanism that involves backside residues of the E2 and LYS-48 of ubiquitin. Biochemistry 2014. [Abstract] EPub
Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA. The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response. Cell 157:565-579, 2014. [Abstract]
Pulliam DA, Deepa SS, Liu Y, Hill S, Lin AL, Bhattacharya A, Shi Y, Sloane L, Viscomi C, Zeviani M, Van Remmen H. Complex IV Deficient Surf1-/- Mice Initiate Mitochondrial Stress Responses. Biochem J 2014. [Abstract] EPub
Shi Y, Ivannikov MV, Walsh ME, Liu Y, Zhang Y, Jaramillo CA, Macleod GT, Van Remmen H. The Lack of CuZnSOD Leads to Impaired Neurotransmitter Release, Neuromuscular Junction Destabilization and Reduced Muscle Strength in Mice. PLoS One 9:e100834, 2014. [Abstract]
* Indicates publications by more than one department or program.
Free Radical Biology & Aging Research Program
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 21
Oklahoma City, OK 73104
Phone: (405) 271-7570
Fax: (405) 271-1437