What We Do
The Coagulation Biology Laboratory, headed by Charles T. Esmon, Ph.D., investigates the fundamental mechanisms involved in blood coagulation, including complex biological processes such as inflammation, cancer and cardiovascular disease.
Dong W, Wang H, Shahzad K, Bock F, Al-Dabet MM, Ranjan S, Wolter J, Kohli S, Hoffmann J, Dhople VM, Zhu C, Lindquist JA, Esmon CT, Grone E, Grone HJ, Madhusudhan T, Mertens PR, Schluter D, Isermann B. Activated protein C ameliorates renal ischemia-reperfusion injury by restricting Y-box binding Protein-1 ubiquitination. J Am Soc Nephrol 2015. [Abstract] EPub
Greineder CF, Brenza JB, Carnemolla R, Zaitsev S, Hood ED, Pan DC, Ding BS, Esmon CT, Chacko AM, Muzykantov VR. Dual targeting of therapeutics to endothelial cells: collaborative enhancement of delivery and effect. FASEB J 2015. [Abstract] EPub
Rathbun S, Tafur A, Grant R, Esmon N, Mauer K, Marlar RA. Comparison of methods to determine rivaroxaban anti-factor Xa activity. Thromb Res 135:394-397, 2015. [Abstract]
Sampath S, Brazier AJ, Avril M, Bernabeu M, Vigdorovich V, Mascarenhas A, Gomes E, Sather DN, Esmon CT, Smith JD. Plasmodium falciparum adhesion domains linked to severe malaria differ in blockade of endothelial protein C receptor. Cell Microbiol 2015. [Abstract] EPub
Schouten M, van 't Veer C, Poulussen N, Meijers JC, Levi M, Esmon CT, van der Poll T. The cytoprotective effects of endogenous activated protein C reduce activation of coagulation during murine pneumococcal pneumonia and sepsis. Thromb Res 135:537-543, 2015. [Abstract]
Starr ME, Takahashi H, Okamura D, Zwischenberger BA, Mrazek AA, Ueda J, Stromberg AJ, Evers BM, Esmon CT, Saito H. Increased coagulation and suppressed generation of activated protein C in aged mice during intra-abdominal sepsis. Am J Physiol Heart Circ Physiol 308:H83-H91, 2015. [Abstract]