Cardiovascular Biology Research Program
What We Do

The Cardiovascular Biology Research Program, headed by Rodger P. McEver, M.D., investigates fundamental mechanisms involved in blood coagulation, inflammation and atherogenesis, with special emphasis on the regulation of these processes.
This program utilizes a multidisciplinary approach to address these questions at a molecular level. This approach encompasses all aspects of modern vascular biology, including structural biology, structure-function analysis of enzymes and receptors, regulation of the relevant genes, in vivo studies using transgenic and gene deletion approaches, cell biology, protein chemistry, physiological studies and spectral and other biophysical methods for analyzing protein-protein, membrane-protein and cell-cell interactions.
The multidisciplinary approach allows identification of new factors and the mechanisms that regulate coagulation and inflammation and enables translation of these findings into an appreciation of their physiological role and clinical relevance. In addition to contributing to a fundamental understanding of these systems, the studies have clinical relevance to heart attack, stroke, septic shock, hemophilia, acute organ rejection in transplantation and miscarriages associated with SLE. Several findings by department members have generated patents and licenses that have led to new diagnostics and therapeutics.
Our Scientists
Our Publications

2013
Ahmed I, Roy B, Chandrakesan P, Venugopal A, Xia L, Jensen R, Anant S, Umar S. Evidence of functional cross talk between the Notch and NF-kappaB pathways in nonneoplastic hyperproliferating colonic epithelium. Am J Physiol Gastrointest Liver Physiol 304:G356-G370, 2013. [Abstract]
Davis RB, Curtis CD, Griffin CT. BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development. Development 140:1272-1281, 2013. [Abstract]
Huang Q, Qin L, Dai S, Zhang H, Pasula S, Zhou H, Chen H, Min W. AIP1 Suppresses Atherosclerosis by Limiting Hyperlipidemia-Induced Inflammation and Vascular Endothelial Dysfunction. Arterioscler Thromb Vasc Biol 33:795-804, 2013. [Abstract]
Johansson ME, Gustafsson JK, Holmen-Larsson J, Jabbar KS, Xia L, Xu H, Ghishan FK, Carvalho FA, Gewirtz AT, Sjovall H, Hansson GC. Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut 2013. [Abstract]
Kim YM, Lee JY, Xia L, Mulvihill JJ, Li S. Trisomy 8: a common finding in mouse embryonic stem (ES) cell lines. Mol Cytogenet 6:3, 2013. [Abstract]
Lupu C, Herlea O, Tang H, Lijnen RH, Lupu F. Plasmin-dependent proteolysis of Tissue Factor Pathway Inhibitor in a mouse model of endotoxemia. J Thromb Haemost 11:142-148, 2013.2013. [Abstract]
Qu H, Ricklin D, Bai H, Chen H, Reis ES, Maciejewski M, Tzekou A, Deangelis RA, Resuello RR, Lupu F, Barlow PN, Lambris JD. New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties. Immunobiology 218:496-505,2013. [Abstract]
Tessneer KL, Pasula S, Cai X, Dong Y, Liu X, Yu L, Hahn S, McManus J, Chen Y, Chang B, Chen H. Endocytic adaptor protein epsin is elevated in prostate cancer and required for cancer progression. ISRN Oncol 2013:420597, 2013. [Abstract]
Wang Y, Zhao L, Suzuki A, Lian L, Min SH, Wang Z, Litvinov RI, Stalker TJ, Yago T, Klopocki AG, Schmidtke DW, Yin H, Choi JK, McEver RP, Weisel JW, Hartwig JH, Abrams CS. Platelets lacking PIP5KIgamma have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion. Blood 2013. [Abstract] EPub
Yao L, Heuser-Baker J, Herlea-Pana O, Barlic-Dicen J. Bone marrow endothelial progenitors in atherosclerotic plaque resolution. Organogenesis 9: 2013. [Abstract] EPub
Zhang Y, Jiang N, Zarnitsyna VI, Klopocki AG, McEver RP, Zhu C. P-selectin glycoprotein ligand-1 forms dimeric interactions with e-selectin but monomeric interactions with L-selectin on cell surfaces. PLoS One 8:e57202, 2013. [Abstract]
* Publications by more than one department
Contact Us

Cardiovascular Biology Research Program
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 45
Oklahoma City, OK 73104
Phone: (405) 271-6480
Fax: (405) 271-3137
Email: Anita-James@omrf.org


