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Cardiovascular Biology Research Program

       What We Do

The Cardiovascular Biology Research Program, headed by Rodger P. McEver, M.D., investigates fundamental mechanisms involved in blood and lymphatic vessel function, atherogenesis, blood coagulation, inflammation, and sepsis.

       Our Publications

2015

Astarita JL, Cremasco V, Fu J, Darnell MC, Peck JR, Nieves-Bonilla JM, Song K, Kondo Y, Woodruff MC, Gogineni A, Onder L, Ludewig B, Weimer RM, Carroll MC, Mooney DJ, Xia L, Turley SJ. The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture. Nat Immunol 16:75-84, 2015. [Abstract]

Chaaban H, Keshari RS, Silasi-Mansat R, Popescu NI, Mehta-D'souza P, Lim YP, Lupu F. Inter-alpha inhibitor protein and its associated glycosaminoglycans protect against histone-induced injury. Blood 2015. [Abstract] EPub

Jackson KW, Christiansen VJ, Yadav VR, Silasi-Mansat R, Lupu F, Awasthi V, Zhang RR, McKee PA. Suppression of tumor growth in mice by rationally designed pseudopeptide inhibitors of fibroblast activation protein and prolyl oligopeptidase. Neoplasia 17:43-54, 2015. [Abstract]

Mastellos DC, Yancopoulou D, Kokkinos P, Huber-Lang M, Hajishengallis G, Biglarnia AR, Lupu F, Nilsson B, Risitano AM, Ricklin D, Lambris JD. Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention. Eur J Clin Invest 2015. [Abstract] EPub

2014

Chen H, Griffin C, Xia L, Srinivasan RS. Molecular and cellular mechanisms of lymphatic vascular maturation. Microvasc Res 96C:16-22, 2014. [Abstract]

Herzog BH, Fu J, Xia L. Mucin-type O-glycosylation is critical for vascular integrity. Glycobiology 24:1237-1241,2014. [Abstract]

Hess PR, Rawnsley DR, Jakus Z, Yang Y, Sweet DT, Fu J, Herzog B, Lu M, Nieswandt B, Oliver G, Makinen T, Xia L, Kahn ML. Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life. J Clin Invest 124:273-284, 2014. [Abstract]

Johansson ME, Gustafsson JK, Holmen-Larsson J, Jabbar KS, Xia L, Xu H, Ghishan FK, Carvalho FA, Gewirtz AT, Sjovall H, Hansson GC. Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut 63:281-291, 2014. [Abstract]

Keshari RS, Silasi-Mansat R, Zhu H, Popescu NI, Peer G, Chaaban H, Lambris JD, Polf H, Lupu C, Kinasewitz G, Lupu F. Acute lung injury and fibrosis in a baboon model of Escherichia coli sepsis. Am J Respir Cell Mol Biol 50:439-450, 2014. [Abstract]

Kwak JY, Mamura M, Barlic-Dicen J, Grage-Griebenow E. Pathophysiological roles of cytokine-chemokine immune network. J Immunol Res 2014;2014:615130. [Abstract]

Lee MY, Skoura A, Park EJ, Landskroner-Eiger S, Jozsef L, Luciano AK, Murata T, Pasula S, Dong Y, Bouaouina M, Calderwood DA, Ferguson SM, De CP, Sessa WC. Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis. Development 141:1465-1472, 2014. [Abstract]

* Liu X, Pasula S, Song H, Tessneer KL, Dong Y, Hahn S, Yago T, Brophy ML, Chang B, Cai X, Wu H, McManus J, Ichise H, Georgescu C, Wren JD, Griffin C, Xia L, Srinivasan RS, Chen H. Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and function. Sci Signal 7:ra97, 2014. [Abstract]

* Lupu F, Keshari RS, Lambris JD, Coggeshall KM. Crosstalk between the coagulation and complement systems in sepsis. Thromb Res 133 Suppl 1:S28-S31, 2014. [Abstract]

McBride J, Jenkins A, Liu X, Zhang B, Lee K, Berry WL, Janknecht R, Griffin C, Aston CE, Lyons T, Tomasek JJ, Ma JX. Elevated circulation levels of an anti-angiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling. J Invest Dermatol 134:1725-1734, 2014. [Abstract]

McNeely T, Shah N, Fridman A, Joshi A, Hartzel J, Keshari R, Lupu F, DiNubile MJ. Mortality among recipients of the Merck V710 staphylococcus aureus vaccine after postoperative S. aureus infections: an analysis of possible contributing host factors. Hum Vaccin Immunother e34407, 2014. [Abstract]

Messa M, Fernandez-Busnadiego R, Sun EW, Chen H, Czapla H, Wrasman K, Wu Y, Ko G, Ross T, Wendland B, De Camilli P. Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits. ELife 3:e03311, 2014. [Abstract]

Pan Y, Wang WD, Yago T. Transcriptional regulation of podoplanin expression by Prox1 in lymphatic endothelial cells. Microvasc Res 94:96-102, 2014. [Abstract]

Pan Y, Yago T, Fu J, Herzog B, McDaniel JM, Mehta-D'souza P, Cai X, Ruan C, McEver RP, West C, Dai K, Chen H, Xia L. Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets. Blood 124:3656-3665, 2014. [Abstract]

Perez-Munoz M, Bergstrom K, Peng V, Schmaltz R, Jimenez-Cardona R, Marsteller N, McGee S, Clavel T, Ley R, Xia L, Peterson D. Discordance between changes in the gut microbiota and pathogenicity in a mouse model of spontaneous colitis. Gut Microbes 5:286-295, 2014. [Abstract]

Risitano AM, Ricklin D, Huang Y, Reis ES, Chen H, Ricci P, Lin Z, Pascariello C, Raia M, Sica M, Del VL, Pane F, Lupu F, Notaro R, Resuello RR, Deangelis RA, Lambris JD. Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria. Blood 123:2094-2101, 2014. [Abstract]

Robinson MR, Moore KL, Brodbelt JS. Direct identification of tyrosine sulfation by using ultraviolet photodissociation mass spectrometry. J Am Soc Mass Spectrom 25:1461-1471, 2014. [Abstract]

Sommer F, Adam N, Johansson ME, Xia L, Hansson GC, Backhed F. Altered mucus glycosylation in core 1 o-glycan-deficient mice affects microbiota composition and intestinal architecture. PLoS One 9:e85254, 2014. [Abstract]

Sreeramkumar V, Adrover JM, Ballesteros I, Cuartero MI, Rossaint J, Bilbao I, Nacher M, Pitaval C, Radovanovic I, Fukui Y, McEver RP, Filippi MD, Lizasoain I, Ruiz-Cabello J, Zarbock A, Moro MA, Hidalgo A. Neutrophils scan for activated platelets to initiate inflammation. Science 346:1234-1238, 2014. [Abstract]

Srinivasan RS, Escobedo N, Yang Y, Interiano A, Dillard ME, Finkelstein D, Mukatira S, Gil HJ, Nurmi H, Alitalo K, Oliver G. The Prox1-Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors. Genes Dev 28:2175-2187, 2014. [Abstract]

Tessneer KL, Pasula S, Cai X, Dong Y, McManus J, Liu X, Yu L, Hahn S, Chang B, Chen Y, Griffin C, Xia L, Adams RH, Chen H. Genetic reduction of vascular endothelial growth factor receptor 2 rescues aberrant angiogenesis caused by epsin deficiency. Arterioscler Thromb Vasc Biol 34:331-337, 2014. [Abstract]

Wang Y, Yago T, Zhang N, Abdisalaam S, Alexandrakis G, Rodgers W, McEver RP. Cytoskeletal regulation of CD44 membrane organization and interactions with E-selectin. J Biol Chem 289:35159-35171, 2014. [Abstract]

Yao L, Herlea-Pana O, Heuser-Baker J, Chen Y, Barlic-Dicen J. Roles of the chemokine system in development of obesity, insulin resistance, and cardiovascular disease. J Immunol Res 2014:181450, 2014. [Abstract]

* Yao L, Heuser-Baker J, Herlea-Pana O, Zhang N, Szweda LI, Griffin TM, Barlic-Dicen J. Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet-induced obesity. FASEB J  28:4534-4550, 2014. [Abstract]

* Publications by more than one department or program

       Contact Us

Cardiovascular Biology Research Program
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 45
Oklahoma City, OK 73104

Phone: (405) 271-6480
Fax: (405) 271-3137
Email:  Anita-James@omrf.org