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Free Radical Biology Metabolic Regulation Journal Club 2011 – 2012 Schedule

 

Presenter Topic Location
Sept. 1 Student: Clair CrewePI: Plafker Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998 Mar 20;92(6):829-39. MC-206 4:00 PM
Sept. 8 Student: Nan Zhang “UCP1-independent Thermogenesis in White Adipose Tissue of Cold-acclimated Ucp1-/- Mice” C-206 4:00 PM
Sept. 15 Student: Xiaolei Liu PI: Lim Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell. 1999 Jul 9;98(1):115-24. C-206 4:00 PM
Sept. 22 Student: Aaron McLain “Peroxisome proliferator–activated receptor g coactivator-1 promotes cardiac mitochondrial biogenesis” John J. Lehman,1 Philip M. Barger,1 Attila Kovacs,1 Jeffrey E. Saffitz,2 Denis M. Medeiros,3 and Daniel P. Kelly1,4; J. Clin. Invest. 106:847–856 (2000). MC-206 4:00 PM
Sept. 29 Student: Yao FuPI: Griffin Puigserver P, Adelmant G, Wu Z, Fan M, Xu J, O’Malley B, Spiegelman BM. Activation of PPARgamma coactivator-1 through transcription factor docking. Science. 1999 Nov 12;286(5443):1368-71 MC-206 4:00 PM
Oct. 6 Post-doc: Rachel Chang “Regulation of CBP-Mediated Transcription by Neuronal Calcium Signaling” MC-206 4:00 PM
Oct. 13 Student: Jolyn Fernandes PI: Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, Bassel-Duby R, Rosenzweig A, Ingwall JS, Spiegelman BM. Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab. 2005 Apr;1(4):259-71. MC-206 4:00 PM
Oct. 20 Student: Rachel BellPI: Humphries Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. 2005 Mar 3;434(7029):113-8. MC-206 4:00 PM
Oct. 27 Cancelled Cancelled MC-206 4:00 PM
Nov. 3 Student: Brittanie Atkinson “Sirtuin 1 (SIRT1) Deacetylase Activity Is Not Required for Mitochondrial Biogenesis or Peroxisome Proliferator-activated Receptor-gamma Coactivator-1alpha (PGC-1alpha) Deacetylation following Endurance Exercise” MC-206 4:00 PM
Nov. 10 Student: Ying WangPI: Szweda Lustig Y, Ruas JL, Estall JL, Lo JC, Devarakonda S, Laznik D, Choi JH, Ono H, Olsen JV, Spiegelman BM. Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase. Genes Dev. 2011 Jun 15;25(12):1232-44. MC-206 4:00 PM
Nov. 17 Student: Lee Bockus “Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity.” MC-206 4:00 PM
Dec. 1 Student: Zhaoyu Liu “PPARα induces PGC-1α gene expression and contributes to the thermogenic activation of brown fat; involvement of PRDM16.” MC-206 4:00 PM
Dec. 8 Visiting Speaker: Debbie Muoio, Duke Univ role of PGC-1alpha as a master metabolic regulator/integrator MC-206 3:30 PM
Jan. 19 organizational meeting MC-206 3:30 PM
Jan. 26 Paul Rindler “Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis.” MC-206 4:00 PM
Feb. 2 Lee Bockus
PI: Tim Griffin		 “Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a- dependent antioxidant defense mechanisms in mice” MC-206 4:00 PM
Feb. 9 Aaron McLain
PI: Tim Griffin		 “Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by Sirt1 Protein-mediated Deacetylation” MC-206 4:00 PM
Feb. 16 OMRF Retreat, no meeting MC-206 4:00 PM
Feb. 23 Rachel Lane
PI: Ken Humphries		 Histone deacetylases 1 and 2 regulate autophagy flux and skeletal muscle
homeostasis in mice.		 MC-206 4:00 PM
Mar. 1 Yao Fu
PI: Luke Szweda		 “Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress.” MC-206 4:00 PM
Mar. 8 Satoshi Matsuzaki
PI: Luke Szweda		 SIRT1-mediated acute cardioprotection.
Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1506-12.
http://www.ncbi.nlm.nih.gov/pubmed/21856913Lysine deacetylation in ischaemic preconditioning: the role of SIRT1.
Cardiovasc Res. 2011 Feb 15;89(3):643-9.”>
http://www.ncbi.nlm.nih.gov/pubmed/20823277		 MC-206 4:00 PM
Mar. 15 Brittanie Atkinson
PI: TBD		 “Resveratrol-mediated SIRT-1 Interactions with p300 Modulate Receptor Activator of NF-kappaB Ligand (RANKL) Activation of NF-kappaB Signaling and Inhibit Osteoclastogenesis in Bone-derived Cells” MC-206 4:00 PM
Mar. 22 Spring Break, no meeting MC-206 4:00 PM
Mar. 29 Jolyn Fernandes
PI: Hui-Ying Lim		 “SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive” MC-206 4:00 PM
Apr. 5 Great Symposium, no meeting MC-206 4:00 PM
Apr. 12 Clair Crewe
PI: Ken Humphries		 “Inactivation of Mitochondrial Aspartate Aminotransferase Contributes to the Respiratory Deficit of Yeast Frataxin-deficient Cells” MC-206 4:00 PM
Apr. 19 Xiaolei Liu
PI: Ann Marie Olson		 “GCN5 Acetyltransferase Complex Controls Glucose Metabolism Through Transcriptional Repression of PGC-1alpha” MC-206 4:00 PM
Apr. 26 Yanfang Pan
PI: Ann Marie Olson		 “Blockade of the nuclear factor-κB pathway in the endothelium prevents insulin resistance and prolongs life spans” MC-206 4:00 PM
May 3 Zhaoyu Liu
PI: Luke Szweda		 “CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis” MC-206 4:00 PM
May 10 Organization Meeting Wrap up session to discuss last semesters papers and decide organizational matters for upcoming semester MC-206 4:00 PM
MC-206 4:00 PM

The Free Radical Biology & Aging Metabolic Regulation Journal Club meets on Thursdays from 4:00 p.m. to 5:00 p.m. in MC-206, unless otherwise posted. To sign up for a particular date contact Tim Griffin at griffint@omrf.org or 271-7579.